node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | PFL_0364 | PFL_0361 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.996 |
hisA | hisD | PFL_0364 | PFL_0929 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.980 |
hisA | hisE | PFL_0364 | PFL_0423 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-ATP diphosphatase; Identified by match to protein family HMM PF01503; match to protein family HMM TIGR03188. | 0.977 |
hisA | hisF | PFL_0364 | PFL_0365 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | PFL_0364 | PFL_0928 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.978 |
hisA | hisH | PFL_0364 | PFL_0362 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI1 | PFL_0364 | PFL_0424 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase 1; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.996 |
hisA | hisI2 | PFL_0364 | PFL_6181 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase 2; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | PFL_0364 | PFL_0570 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.902 |
hisB | hisA | PFL_0361 | PFL_0364 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.996 |
hisB | hisD | PFL_0361 | PFL_0929 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisE | PFL_0361 | PFL_0423 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | phosphoribosyl-ATP diphosphatase; Identified by match to protein family HMM PF01503; match to protein family HMM TIGR03188. | 0.975 |
hisB | hisF | PFL_0361 | PFL_0365 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | PFL_0361 | PFL_0928 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.980 |
hisB | hisH | PFL_0361 | PFL_0362 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI1 | PFL_0361 | PFL_0424 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | phosphoribosyl-AMP cyclohydrolase 1; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.954 |
hisB | hisI2 | PFL_0361 | PFL_6181 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | phosphoribosyl-AMP cyclohydrolase 2; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.954 |
hisB | hisZ | PFL_0361 | PFL_0570 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.924 |
hisD | hisA | PFL_0929 | PFL_0364 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.980 |
hisD | hisB | PFL_0929 | PFL_0361 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.997 |