node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
amtB | glnD | PFL_6019 | PFL_1174 | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.721 |
amtB | glnE | PFL_6019 | PFL_0510 | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | [glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | 0.638 |
amtB | glnK | PFL_6019 | PFL_6020 | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Nitrogen regulatory protein P-II; Identified by similarity to SP:P0AC55; match to protein family HMM PF00543; Belongs to the P(II) protein family. | 0.999 |
amtB | glnL | PFL_6019 | PFL_0378 | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Nitrogen regulation protein NR(II); Identified by similarity to SP:P06712; match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM PF08448. | 0.699 |
amtB | gltB | PFL_6019 | PFL_0453 | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.831 |
dapC | glnD | PFL_1173 | PFL_1174 | Succinyldiaminopimelate transaminase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR03538. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.695 |
dapC | gltB | PFL_1173 | PFL_0453 | Succinyldiaminopimelate transaminase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR03538. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.532 |
dapC | map_1 | PFL_1173 | PFL_1175 | Succinyldiaminopimelate transaminase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR03538. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.618 |
glnA_2 | glnD | PFL_0386 | PFL_1174 | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.542 |
glnA_2 | glnE | PFL_0386 | PFL_0510 | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | [glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | 0.657 |
glnA_2 | glnK | PFL_0386 | PFL_6020 | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Nitrogen regulatory protein P-II; Identified by similarity to SP:P0AC55; match to protein family HMM PF00543; Belongs to the P(II) protein family. | 0.709 |
glnA_2 | glnL | PFL_0386 | PFL_0378 | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Nitrogen regulation protein NR(II); Identified by similarity to SP:P06712; match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM PF08448. | 0.405 |
glnA_2 | gltB | PFL_0386 | PFL_0453 | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.972 |
glnD | amtB | PFL_1174 | PFL_6019 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Ammonium transporter; Identified by similarity to SP:P69681; match to protein family HMM PF00909; match to protein family HMM TIGR00836. | 0.721 |
glnD | dapC | PFL_1174 | PFL_1173 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Succinyldiaminopimelate transaminase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR03538. | 0.695 |
glnD | glnA_2 | PFL_1174 | PFL_0386 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Glutamine synthetase, type I; Identified by similarity to SP:P0A9C5; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | 0.542 |
glnD | glnE | PFL_1174 | PFL_0510 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | [glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] | 0.904 |
glnD | glnG | PFL_1174 | PFL_0377 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Nitrogen regulation protein; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. | 0.529 |
glnD | glnK | PFL_1174 | PFL_6020 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Nitrogen regulatory protein P-II; Identified by similarity to SP:P0AC55; match to protein family HMM PF00543; Belongs to the P(II) protein family. | 0.951 |
glnD | glnL | PFL_1174 | PFL_0378 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Nitrogen regulation protein NR(II); Identified by similarity to SP:P06712; match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM PF08448. | 0.571 |