node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_0316 | PFL_5458 | PFL_0316 | PFL_5458 | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | Identified by match to protein family HMM PF01569; match to protein family HMM PF09335. | 0.657 |
PFL_0316 | PFL_5894 | PFL_0316 | PFL_5894 | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | 0.451 |
PFL_0316 | murA | PFL_0316 | PFL_0927 | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.441 |
PFL_0316 | murE | PFL_0316 | PFL_5066 | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.428 |
PFL_0316 | uppP | PFL_0316 | PFL_3114 | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.538 |
PFL_3113 | uppP | PFL_3113 | PFL_3114 | Conserved hypothetical protein; Identified by match to protein family HMM PF06961. | Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.802 |
PFL_5458 | PFL_0316 | PFL_5458 | PFL_0316 | Identified by match to protein family HMM PF01569; match to protein family HMM PF09335. | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | 0.657 |
PFL_5458 | murG | PFL_5458 | PFL_5061 | Identified by match to protein family HMM PF01569; match to protein family HMM PF09335. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.402 |
PFL_5458 | uppP | PFL_5458 | PFL_3114 | Identified by match to protein family HMM PF01569; match to protein family HMM PF09335. | Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.546 |
PFL_5894 | PFL_0316 | PFL_5894 | PFL_0316 | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719. | 0.451 |
PFL_5894 | mraY | PFL_5894 | PFL_5064 | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.907 |
PFL_5894 | uppP | PFL_5894 | PFL_3114 | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.926 |
PFL_5894 | uppS | PFL_5894 | PFL_1180 | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.917 |
mraY | PFL_5894 | PFL_5064 | PFL_5894 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Phosphatidylglycerophosphatase B-like protein; Identified by match to protein family HMM PF01569. | 0.907 |
mraY | murA | PFL_5064 | PFL_0927 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.775 |
mraY | murD | PFL_5064 | PFL_5063 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.983 |
mraY | murE | PFL_5064 | PFL_5066 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.969 |
mraY | murG | PFL_5064 | PFL_5061 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.998 |
mraY | uppP | PFL_5064 | PFL_3114 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl-diphosphatase UppP; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.929 |
mraY | uppS | PFL_5064 | PFL_1180 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.579 |