node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_4778 | cobB | PFL_4778 | PFL_4430 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.922 |
PFL_4778 | cobC-2 | PFL_4778 | PFL_4427 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140. | 0.920 |
PFL_4778 | cobD | PFL_4778 | PFL_4428 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.932 |
PFL_4778 | cobJ | PFL_4778 | PFL_0660 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | CbiG protein/precorrin-3B C17-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01466. | 0.541 |
PFL_4778 | cobO | PFL_4778 | PFL_4431 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.942 |
PFL_4778 | cobQ | PFL_4778 | PFL_4426 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.924 |
PFL_4778 | cobS | PFL_4778 | PFL_4422 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.931 |
PFL_4778 | cobT | PFL_4778 | PFL_4424 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.419 |
PFL_4778 | cobU | PFL_4778 | PFL_4425 | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | Adenosylcobinamide kinase/adenosylcobinamidephosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.930 |
cobB | PFL_4778 | PFL_4430 | PFL_4778 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | ATP:cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF01923; match to protein family HMM TIGR00636; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.922 |
cobB | cobC | PFL_4430 | PFL_4423 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Alpha-ribazole phosphatase; Identified by match to protein family HMM PF00300; match to protein family HMM TIGR03162. | 0.827 |
cobB | cobC-2 | PFL_4430 | PFL_4427 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Threonine-phosphate decarboxylase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01140. | 0.956 |
cobB | cobD | PFL_4430 | PFL_4428 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.979 |
cobB | cobJ | PFL_4430 | PFL_0660 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CbiG protein/precorrin-3B C17-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01466. | 0.956 |
cobB | cobO | PFL_4430 | PFL_4431 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.994 |
cobB | cobQ | PFL_4430 | PFL_4426 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.990 |
cobB | cobS | PFL_4430 | PFL_4422 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.949 |
cobB | cobT | PFL_4430 | PFL_4424 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.982 |
cobB | cobU | PFL_4430 | PFL_4425 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide kinase/adenosylcobinamidephosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.978 |
cobC | cobB | PFL_4423 | PFL_4430 | Alpha-ribazole phosphatase; Identified by match to protein family HMM PF00300; match to protein family HMM TIGR03162. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.827 |