node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OB0545 | OB0546 | gene:10732749 | gene:10732750 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | 0.998 |
OB0545 | OB0547 | gene:10732749 | gene:10732751 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.976 |
OB0545 | OB0548 | gene:10732749 | gene:10732752 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosyl formimino-5-aminoimidazole isomerase; CDS_ID OB0548. | 0.971 |
OB0545 | OB0549 | gene:10732749 | gene:10732753 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.976 |
OB0545 | OB0550 | gene:10732749 | gene:10732754 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; CDS_ID OB0550. | 0.999 |
OB0545 | OB0551 | gene:10732749 | gene:10732755 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
OB0545 | OB0552 | gene:10732749 | gene:10732756 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.978 |
OB0545 | OB0553 | gene:10732749 | gene:10732757 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | histidine-tRNA ligase (histidyl-tRNA synthetase); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.954 |
OB0545 | hisC | gene:10732749 | gene:10734022 | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol-phosphate aminotransferase; CDS_ID OB1782; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.910 |
OB0546 | OB0545 | gene:10732750 | gene:10732749 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
OB0546 | OB0547 | gene:10732750 | gene:10732751 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
OB0546 | OB0548 | gene:10732750 | gene:10732752 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Phosphoribosyl formimino-5-aminoimidazole isomerase; CDS_ID OB0548. | 0.999 |
OB0546 | OB0549 | gene:10732750 | gene:10732753 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
OB0546 | OB0550 | gene:10732750 | gene:10732754 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Imidazoleglycerol-phosphate dehydratase; CDS_ID OB0550. | 0.999 |
OB0546 | OB0551 | gene:10732750 | gene:10732755 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
OB0546 | OB0552 | gene:10732750 | gene:10732756 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
OB0546 | OB0553 | gene:10732750 | gene:10732757 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | histidine-tRNA ligase (histidyl-tRNA synthetase); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.999 |
OB0546 | hisC | gene:10732750 | gene:10734022 | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | Histidinol-phosphate aminotransferase; CDS_ID OB1782; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.995 |
OB0547 | OB0545 | gene:10732751 | gene:10732749 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Histidinol-phosphate aminotransferase; CDS_ID OB0545; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.976 |
OB0547 | OB0546 | gene:10732751 | gene:10732750 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Histidine biosynthesis bifunctional protein HisIE; CDS_ID OB0546; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |