node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OB0010 | OB0078 | gene:10732171 | gene:10732241 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |
OB0010 | OB1061 | gene:10732171 | gene:10733299 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.949 |
OB0010 | OB1507 | gene:10732171 | gene:10733747 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.465 |
OB0010 | OB2105 | gene:10732171 | gene:10734353 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.940 |
OB0010 | OB2373 | gene:10732171 | gene:10734624 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.923 |
OB0010 | guaA | gene:10732171 | gene:10732937 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
OB0010 | ndk | gene:10732171 | gene:10734027 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.560 |
OB0078 | OB0010 | gene:10732241 | gene:10732171 | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.946 |
OB0078 | OB1061 | gene:10732241 | gene:10733299 | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.929 |
OB0078 | OB2105 | gene:10732241 | gene:10734353 | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.912 |
OB0078 | OB2373 | gene:10732241 | gene:10734624 | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.903 |
OB0078 | guaA | gene:10732241 | gene:10732937 | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.950 |
OB1061 | OB0010 | gene:10733299 | gene:10732171 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.949 |
OB1061 | OB0078 | gene:10733299 | gene:10732241 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | Hypoxanthine phosphoribosyltransferase; CDS_ID OB0078; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.929 |
OB1061 | OB2105 | gene:10733299 | gene:10734353 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | Hypothetical conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.922 |
OB1061 | OB2373 | gene:10733299 | gene:10734624 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.906 |
OB1061 | guaA | gene:10733299 | gene:10732937 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.996 |
OB1507 | OB0010 | gene:10733747 | gene:10732171 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.465 |
OB1507 | OB2105 | gene:10733747 | gene:10734353 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Hypothetical conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.686 |
OB1507 | guaA | gene:10733747 | gene:10732937 | Hypothetical conserved protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.499 |