node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OB0036 | OB1740 | gene:10732198 | gene:10733980 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
OB0036 | OB1980 | gene:10732198 | gene:10734226 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | 0.933 |
OB0036 | OB2373 | gene:10732198 | gene:10734624 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.912 |
OB0036 | tdk | gene:10732198 | gene:10735251 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | Thymidine kinase; CDS_ID OB2999. | 0.942 |
OB1740 | OB0036 | gene:10733980 | gene:10732198 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.944 |
OB1740 | OB1980 | gene:10733980 | gene:10734226 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | 0.944 |
OB1740 | OB2373 | gene:10733980 | gene:10734624 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.914 |
OB1740 | pdp | gene:10733980 | gene:10734084 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Pyrimidine-nucleoside phosphorylase; CDS_ID OB1844. | 0.402 |
OB1740 | tdk | gene:10733980 | gene:10735251 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Thymidine kinase; CDS_ID OB2999. | 0.969 |
OB1980 | OB0036 | gene:10734226 | gene:10732198 | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
OB1980 | OB1740 | gene:10734226 | gene:10733980 | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
OB1980 | OB2373 | gene:10734226 | gene:10734624 | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.904 |
OB1980 | tdk | gene:10734226 | gene:10735251 | Late competence protein (DNA binding and uptake); CDS_ID OB1980. | Thymidine kinase; CDS_ID OB2999. | 0.932 |
OB2345 | OB2373 | gene:10734596 | gene:10734624 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | 0.902 |
OB2345 | cdd | gene:10734596 | gene:10733991 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Cytidine:deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.934 |
OB2345 | pdp | gene:10734596 | gene:10734084 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Pyrimidine-nucleoside phosphorylase; CDS_ID OB1844. | 0.953 |
OB2345 | pnp | gene:10734596 | gene:10734085 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.932 |
OB2345 | tdk | gene:10734596 | gene:10735251 | Purine nucleoside phosphorylase; CDS_ID OB2345. | Thymidine kinase; CDS_ID OB2999. | 0.928 |
OB2373 | OB0036 | gene:10734624 | gene:10732198 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
OB2373 | OB1740 | gene:10734624 | gene:10733980 | Hypothetical conserved protein; CDS_ID OB2373; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.914 |