node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NSE_0611 | bioB | NSE_0611 | NSE_0612 | Hypothetical protein; Identified by Glimmer2; putative. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.773 |
NSE_0693 | bioA | NSE_0693 | NSE_0618 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.525 |
NSE_0693 | bioB | NSE_0693 | NSE_0612 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.954 |
NSE_0693 | bioD | NSE_0693 | NSE_0617 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.544 |
NSE_0693 | folD | NSE_0693 | NSE_0821 | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.461 |
argD | bioB | NSE_0850 | NSE_0612 | Acetylornithine aminotransferase; Identified by similarity to SP:P54752; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.681 |
argD | hemA | NSE_0850 | NSE_0826 | Acetylornithine aminotransferase; Identified by similarity to SP:P54752; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202; match to protein family HMM TIGR01821. | 0.622 |
bioA | NSE_0693 | NSE_0618 | NSE_0693 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.525 |
bioA | bioB | NSE_0618 | NSE_0612 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.990 |
bioA | bioD | NSE_0618 | NSE_0617 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioA | bioF | NSE_0618 | NSE_0613 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Identified by similarity to SP:P53556; match to protein family HMM PF00155. | 0.991 |
bioA | hemA | NSE_0618 | NSE_0826 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202; match to protein family HMM TIGR01821. | 0.721 |
bioB | NSE_0611 | NSE_0612 | NSE_0611 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Hypothetical protein; Identified by Glimmer2; putative. | 0.773 |
bioB | NSE_0693 | NSE_0612 | NSE_0693 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.954 |
bioB | argD | NSE_0612 | NSE_0850 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Acetylornithine aminotransferase; Identified by similarity to SP:P54752; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.681 |
bioB | bioA | NSE_0612 | NSE_0618 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.990 |
bioB | bioD | NSE_0612 | NSE_0617 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioB | bioF | NSE_0612 | NSE_0613 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 8-amino-7-oxononanoate synthase; Identified by similarity to SP:P53556; match to protein family HMM PF00155. | 0.901 |
bioB | folD | NSE_0612 | NSE_0821 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.700 |
bioB | hemA | NSE_0612 | NSE_0826 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202; match to protein family HMM TIGR01821. | 0.743 |