node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAO54229.1 | AAO54230.1 | PSPTO_0687 | PSPTO_0688 | Conserved domain protein; See PMID:20190049 for expression data. | Lipoprotein, putative; See PMID:20190049 for expression data. | 0.815 |
AAO54229.1 | nrdR | PSPTO_0687 | PSPTO_0689 | Conserved domain protein; See PMID:20190049 for expression data. | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.561 |
AAO54229.1 | ribBA-1 | PSPTO_0687 | PSPTO_0692 | Conserved domain protein; See PMID:20190049 for expression data. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.518 |
AAO54229.1 | ribD | PSPTO_0687 | PSPTO_0690 | Conserved domain protein; See PMID:20190049 for expression data. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.608 |
AAO54229.1 | ribE | PSPTO_0687 | PSPTO_0691 | Conserved domain protein; See PMID:20190049 for expression data. | Riboflavin synthase, alpha subunit; See PMID:20190049 for expression data. | 0.481 |
AAO54230.1 | AAO54229.1 | PSPTO_0688 | PSPTO_0687 | Lipoprotein, putative; See PMID:20190049 for expression data. | Conserved domain protein; See PMID:20190049 for expression data. | 0.815 |
AAO54230.1 | nrdR | PSPTO_0688 | PSPTO_0689 | Lipoprotein, putative; See PMID:20190049 for expression data. | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.578 |
AAO54230.1 | ribBA-1 | PSPTO_0688 | PSPTO_0692 | Lipoprotein, putative; See PMID:20190049 for expression data. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.515 |
AAO54230.1 | ribD | PSPTO_0688 | PSPTO_0690 | Lipoprotein, putative; See PMID:20190049 for expression data. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.607 |
AAO54230.1 | ribE | PSPTO_0688 | PSPTO_0691 | Lipoprotein, putative; See PMID:20190049 for expression data. | Riboflavin synthase, alpha subunit; See PMID:20190049 for expression data. | 0.481 |
birA | nrdA | PSPTO_0610 | PSPTO_1671 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.414 |
birA | nrdR | PSPTO_0610 | PSPTO_0689 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.535 |
birA | ribBA-1 | PSPTO_0610 | PSPTO_0692 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.598 |
birA | ribD | PSPTO_0610 | PSPTO_0690 | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.616 |
nrdA | birA | PSPTO_1671 | PSPTO_0610 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.414 |
nrdA | nrdR | PSPTO_1671 | PSPTO_0689 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.623 |
nrdA | polI | PSPTO_1671 | PSPTO_0344 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.806 |
nrdA | ribD | PSPTO_1671 | PSPTO_0690 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.478 |
nrdR | AAO54229.1 | PSPTO_0689 | PSPTO_0687 | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Conserved domain protein; See PMID:20190049 for expression data. | 0.561 |
nrdR | AAO54230.1 | PSPTO_0689 | PSPTO_0688 | Conserved protein of unknown function; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Lipoprotein, putative; See PMID:20190049 for expression data. | 0.578 |