STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hopAB2Type III effector HopAB2; Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, [...] (553 aa)    
Predicted Functional Partners:
fliC
Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
      
 0.846
hopF2
Type III effector HopF2; This gene has an isoleucine start. Previously known as HolPtoAD (PMID11872842; Guttman et al, 2002) and HopPtoF (PMID11854524; Fouts et al, 2002); see PMID:20190049 for expression data; similar to GP:7677395; identified by sequence similarity; putative.
      
 0.768
hopM1
Type III effector HopM1; Involved in the suppression of basal resistance and promotion of disease symptoms in plants. Mediates the ubiquitination and degradation, via the host proteasome, of a low-abundance immunity- associated protein in Arabidopsis thaliana. May be involved in the inhibition of a host vesicle trafficking pathway.
      
 0.757
hopAI1
Type III effector HopAI1; Previously known as HolPtoAI (PMID12615215; Greenberg and Vinatzer, 2003); similar to SP:P21456, GB:M33318, GB:X13897, GB:X13929, GB:X06401, GB:X13930, SP:P11509, SP:P20853, PID:180987, PID:29547, PID:30332, and PID:825700; identified by sequence similarity; putative.
      
 0.700
hopU1
Type III effector HopU1; Previously known as HopPtoS2 (PMID12032338; Petnicki-Ocwieja et al, 2002).
      
 0.569
hrcC
Outer-membrane type III secretion protein HrcC; Similar to GP:3228547, GB:M96789, SP:P35212, and PID:183223; identified by sequence similarity; putative; see PMID:20190049 for expression data; similar to GP:3228547, GB:M96789, SP:P35212, and PID:183223, identified by sequence similarity, putative.
      
 0.518
hopQ1-1
Type III effector HopQ1-1; Previously known as ORF19 (PMID12032338; Petnicki-Ocwieja et al, 2002) and HolPtoQ (PMID11872842; Guttman et al, 2002); similar to GP:17427254, and GP:19071520; identified by sequence similarity; putative; see PMID:20190049 for expression data; Previously known as ORF19; PMID12032338, Petnicki-Ocwieja et al, 2002; and HolPtoQ; PMID1187284, Guttman et al, 2002; , see PMID:20190049 for expression data; similar to GP:17427254, and GP:19071520, identified by sequence similarity, putative.
      
 0.505
hopAO1
Type III effector HopAO1; Effector showing tyrosine-phosphatase activity required for host defense suppression. Functions inside plant cells causing suppression of HR (hypersensitive response), PR1 gene expression and oxidative burst probably by interfering with a MAPK (mitogen-activated protein kinase) pathway. MAPK cascades are known to activate defense- related transcription factors. Inhibits plant pattern-recognition receptors (PRRs) activation.
      
 0.503
hopE1
Type III effector HopE1; Previously known as HolPtoV (PMID11872842; Guttman et al, 2002) and HopPtoE (PMID12032338; Petnicki-Ocwieja et al, 2002); see PMID:20190049 for expression data.
      
 0.459
hopG1
Type III effector HopG1; Previously known as HolPtoW (PMID11872842; Guttman et al, 2002) and HopPtoG (PMID12032338; Petnicki-Ocwieja et al, 2002); see PMID:20190049 for expression data.
      
 0.459
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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