STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hopAO1Type III effector HopAO1; Effector showing tyrosine-phosphatase activity required for host defense suppression. Functions inside plant cells causing suppression of HR (hypersensitive response), PR1 gene expression and oxidative burst probably by interfering with a MAPK (mitogen-activated protein kinase) pathway. MAPK cascades are known to activate defense- related transcription factors. Inhibits plant pattern-recognition receptors (PRRs) activation. (468 aa)    
Predicted Functional Partners:
AAO54070.1
Hypothetical protein; Identified by Glimmer2; putative.
   
 0.749
hopV1
Type III effector HopV1; See PMID:20190049 for expression data; identified by Glimmer.
     
 0.558
hopAI1
Type III effector HopAI1; Previously known as HolPtoAI (PMID12615215; Greenberg and Vinatzer, 2003); similar to SP:P21456, GB:M33318, GB:X13897, GB:X13929, GB:X06401, GB:X13930, SP:P11509, SP:P20853, PID:180987, PID:29547, PID:30332, and PID:825700; identified by sequence similarity; putative.
      
 0.530
cfa6
Coronafacic acid polyketide synthase I; This gene is the first of two multimodular polyketide synthetases involved in the biosynthesis of coronafacic acid. This synthetase is proposed to receive CPC (2-carboxy-2-cyclopentenone) from an acyl carrier protein (cfa1), it then adds a buyrate group and then completely reduces the ketone of the (former) carboxylate group. The resulting product is then passed to the second polyketide synthetase (cfa7); similar to GP:13346874; identified by sequence similarity; putative; see PMID:20190049 for expression data; This gene is the first of two multi [...]
  
 
 0.520
hopAF1
Type III effector HopAF1; Previously known as HolPtoN (PMID11872842; Guttman et al, 2002) and HopPtoJ (PMID12032338; Petnicki-Ocwieja et al, 2002); see PMID:20190049 for expression data.
      
 0.514
hopF2
Type III effector HopF2; This gene has an isoleucine start. Previously known as HolPtoAD (PMID11872842; Guttman et al, 2002) and HopPtoF (PMID11854524; Fouts et al, 2002); see PMID:20190049 for expression data; similar to GP:7677395; identified by sequence similarity; putative.
      
 0.506
hopAB2
Type III effector HopAB2; Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, [...]
      
 0.503
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
    
  0.503
shcV
Type III chaperone ShcV; See PMID:20190049 for expression data; identified by Glimmer.
     
 0.499
cdsA-2
Phosphatidate cytidylyltransferase; Identified by match to PFAM protein family HMM PF01148.
  
    0.470
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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