STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yndHConserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. (205 aa)    
Predicted Functional Partners:
yndJ
Putative integral inner membrane protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component.
 
    0.974
yndG
Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function.
  
    0.900
yndK
Putative phage/plasmid replication protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin.
  
    0.739
yfiJ
Two-component sensor histidine kinase [YfiK]; Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation. May also promote biofilm formation.
   
    0.618
estB
Secreted esterase / lipase; An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (less than C10) with the maximum activity towards tricaprylin (C8:0). Active against p- nitrophenylesters with fatty acid chain lengths from C6 to C18.
   
    0.545
ecsC
Putative hydrolase; Unknown, does not resemble components of ABC transporters.
   
    0.512
yndE
Putative spore germination integral inner membrane protein; Involved in the germinative response to L-alanine. Could be an amino acid transporter (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.
  
    0.494
yndF
Putative spore germination lipoprotein; May be involved in spore germination. Belongs to the GerABKC lipoprotein family.
       0.478
flgM
Anti-sigma factor repressor of sigma(D)-dependent transcription; Allows the coupling of early and late flagellar synthesis through the repression of RNA polymerase sigma-D factor-dependent transcription.
  
     0.466
yndD
Putative spore germination protein; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
       0.425
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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