STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (490 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD); Belongs to the NadD family.
 
 
 0.997
nadC
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA).
  
 0.994
pncA
Nicotinamidase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme; Belongs to the isochorismatase family.
 
  
 0.989
cinA
Competence-damage inducible regulator; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CinA family.
  
 
 0.954
nadE
Ammonium-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
  
 0.947
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
   
  
 0.934
nadA
Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
  
  
 0.933
niaR
Transcriptional repressor of de novo NAD biosynthesis; In the presence of nicotinic acid represses transcription of the nadBCA and nifS-nadR operons. Also binds to DNA upstream of the niaP gene, probably regulating it as well. May bind nicotinic acid.
  
  
 0.928
pupG
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
  
 
 0.921
deoD
Purine nucleoside phosphorylase; Cleavage of adenosine and its derivatives; Belongs to the PNP/UDP phosphorylase family.
   
 
 0.917
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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