node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
sdpA | sdpB | BSU33750 | BSU33760 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | 0.998 |
sdpA | skfA | BSU33750 | BSU01910 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | 0.765 |
sdpA | skfB | BSU33750 | BSU01920 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Synthesis of sporulation killing factor A; Catalyzes the formation of the thioether bond required for production of the sporulation killing factor (SKF) from SkfA. Forms the cysteine-methionine thioether bond found in SKF; the acceptor amino acid can be hydrophobic, aromatic or a small hydrophilic amino acid but not a larger hydrophilic amino acid, i.e. Met=Ala, Phe, Leu, Tyr>Asn, Ser>>Gln, Glu, Lys. The relative position of Cys and Met in the substrate cannot be inverted, in vitro the thioether bond cannot be made in the absence of the SkfA propeptide, suggesting this is the first rea [...] | 0.525 |
sdpA | spbC | BSU33750 | BSU33770 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...] | 0.982 |
sdpA | tapA | BSU33750 | BSU24640 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. | 0.528 |
sdpA | yfmG | BSU33750 | BSU07480 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.532 |
sdpA | yitM | BSU33750 | BSU11040 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.512 |
sdpA | yitO | BSU33750 | BSU11055 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Putative integral inner membrane protein with HTTM domain; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm: putative membrane component. | 0.847 |
sdpA | yydG | BSU33750 | BSU40170 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Putative AdoMet radical enzyme; Required for production of the modified peptide YydF (Probable). May activate a metalloenzyme (Potential). | 0.713 |
sdpA | yydI | BSU33750 | BSU40150 | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | ABC transporter (ATP-binding protein); Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF (Probable). Responsible for energy coupling to the transport system (By similarity). | 0.520 |
sdpB | sdpA | BSU33760 | BSU33750 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | 0.998 |
sdpB | spbC | BSU33760 | BSU33770 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...] | 0.983 |
sdpB | yfmG | BSU33760 | BSU07480 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.621 |
sdpB | yitM | BSU33760 | BSU11040 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Conserved hypothetical protein; Evidence 4: Homologs of previously reported genes of unknown function. | 0.588 |
sdpB | yydG | BSU33760 | BSU40170 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | Putative AdoMet radical enzyme; Required for production of the modified peptide YydF (Probable). May activate a metalloenzyme (Potential). | 0.693 |
sdpB | yydI | BSU33760 | BSU40150 | Exporter of killing factor SpbC; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | ABC transporter (ATP-binding protein); Suggested to be part of an ABC transporter complex YydIJ involved in export of the modified peptide YydF (Probable). Responsible for energy coupling to the transport system (By similarity). | 0.502 |
skfA | sdpA | BSU01910 | BSU33750 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Export of killing factor; Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation. | 0.765 |
skfA | skfB | BSU01910 | BSU01920 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Synthesis of sporulation killing factor A; Catalyzes the formation of the thioether bond required for production of the sporulation killing factor (SKF) from SkfA. Forms the cysteine-methionine thioether bond found in SKF; the acceptor amino acid can be hydrophobic, aromatic or a small hydrophilic amino acid but not a larger hydrophilic amino acid, i.e. Met=Ala, Phe, Leu, Tyr>Asn, Ser>>Gln, Glu, Lys. The relative position of Cys and Met in the substrate cannot be inverted, in vitro the thioether bond cannot be made in the absence of the SkfA propeptide, suggesting this is the first rea [...] | 0.986 |
skfA | spbC | BSU01910 | BSU33770 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Killing factor SdpC; Produces a 42-residue extracellular sporulation delaying protein (SDP) that collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, which leads to autolysis; may form a proton channel. Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, inducing cannibalism to provide a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Addition of SDP to liquid cultures halts growth [...] | 0.947 |
skfA | tapA | BSU01910 | BSU24640 | Sporulation killing factor A; Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation. Can also inhibit growth of other bacteria at high concentrations. Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344). Has a role in protecting the secreted lipase LipA against pro [...] | Lipoprotein for biofilm formation; Required for biofilm formation. Required for the proper anchoring and polymerization of TasA amyloid fibers at the cell surface. Is also a minor component of TasA fibers. | 0.491 |