STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccpBTranscriptional repressor of carbon supply (laci family); Transcriptional regulator involved in catabolite repression of several operons (311 aa)    
Predicted Functional Partners:
msmR
Transcriptional regulator (laci family); Represses the melibiose operon melREDCA in the absence of melibiose or raffinose. Binds to two binding sites at the promoter region of the operon
  
     0.725
exoA
Apurinic/apyrimidinic endonuclease; Exodeoxyribonuclease; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type e: enzyme
       0.671
yyaH
Lactoylglutathione lyase; Uncharacterized protein YyaH; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme
       0.668
maa
Maltose o-acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to maltose and other sugars. Acetylates glucose exclusively at the C6 position and maltose at the C6 position of the non-reducing end glucosyl moiety. Is able to acetylate maltooligosaccharides
       0.639
fruR
Deor family transcriptional regulator, fructose operon transcriptional repressor; Uncharacterized HTH-type transcriptional regulator FruR; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type r: regulator
  
 
 
 0.594
rtpA
Tryptophan rna-binding attenuator protein inhibitory protein; By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP
      
 0.582
arfM
Transcription regulator arfm; Activates, in anaerobic conditions, the transcription of the fermentative operons lctEP and alsDS, of the hmp gene encoding a flavohemoglobin-like protein, the nitrite reductase operon nasDE and the heme biosynthesis genes hemN and hemZ
    
 
 0.550
cysL
Lysr family transcriptional regulator, transcriptional activator of the cysji operon; Transcriptional activator of the cysJI operon which is involved in sulfur assimilation. Also negatively regulates its own transcription
  
   
 0.518
rpsR
Small subunit ribosomal protein s18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
       0.512
ytrA
Transcriptional regulator (gntr family); Negatively regulates ABC transporter complex ytrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation
  
   
 0.500
Your Current Organism:
Bacillus subtilis
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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