STRINGSTRING
dfrA protein (Bacillus subtilis 168) - STRING interaction network
"dfrA" - Dihydrofolate reductase in Bacillus subtilis 168
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dfrADihydrofolate reductase (EC-1.5.1.3); Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) (168 aa)    
Predicted Functional Partners:
thyA2
Thymidylate synthase (EC-2.1.1.45); Provides the sole de novo source of dTMP for DNA biosynthesis (264 aa)
 
  0.999
thyA1
Thymidylate synthase (EC-2.1.1.45); Provides the sole de novo source of dTMP for DNA biosynthesis (279 aa)
 
  0.999
folC
Folylpolyglutamate synthase (EC-6.3.2.17); Conversion of folates to polyglutamate derivatives. It prefers 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate (430 aa)
   
  0.982
glyA
Serine hydroxymethyltransferase (EC-2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) (415 aa)
   
  0.981
gcvT
Aminomethyltransferase (EC-2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine (362 aa)
   
 
  0.961
fmt
methionyl-tRNA formyltransferase (EC-2.1.2.9); Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) (317 aa)
   
 
  0.917
purH
Bifunctional purine biosynthesis protein PurH (EC-2.1.2.3 3.5.4.10) (512 aa)
     
    0.911
purN
Phosphoribosylglycinamide formyltransferase (EC-2.1.2.2); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (195 aa)
     
 
  0.904
purT
Phosphoribosylglycinamide formyltransferase (EC-2.1.2.-); Catalyzes two reactions- the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP (384 aa)
 
 
    0.902
purU
Formyltetrahydrofolate deformylase (EC-3.5.1.10); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (300 aa)
         
  0.901
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis, B. subtilis subsp. subtilis, B. subtilis subsp. subtilis str. 168, Bacillus globigii, Bacillus natto, Bacillus sp. 15:2, Bacillus sp. RSP-GLU, Bacillus sp. S2 BC-1, Bacillus subtilis, Bacillus subtilis 168, Bacillus subtilis subsp. subtilis, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700, Bacillus subtilis/Bacillus globigii, Bacillus uniflagellatus, Vibrio subtilis
Server load: low (20%) [HD]