Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BB_0826 | hrpA | BB_0826 | BB_0827 | Conserved hypothetical protein. | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | 0.922 |
| BB_0826 | sbcD | BB_0826 | BB_0829 | Conserved hypothetical protein. | Putative Exonuclease SbcD homolog; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity); Belongs to the SbcD family. | 0.403 |
| BB_0826 | topA | BB_0826 | BB_0828 | Conserved hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.845 |
| BB_0830 | hrpA | BB_0830 | BB_0827 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | 0.603 |
| BB_0830 | polA | BB_0830 | BB_0548 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | DNA polymerase I superfamily; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
| BB_0830 | recA | BB_0830 | BB_0131 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.908 |
| BB_0830 | sbcD | BB_0830 | BB_0829 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | Putative Exonuclease SbcD homolog; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity); Belongs to the SbcD family. | 0.999 |
| BB_0830 | ssb | BB_0830 | BB_0114 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | Single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein); Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | 0.494 |
| BB_0830 | topA | BB_0830 | BB_0828 | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.985 |
| gyrB | leuS | BB_0436 | BB_0251 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | leucyl-tRNA synthetase; Identified by match to protein family HMM PF00133; match to protein family HMM PF08264; match to protein family HMM PF09334; match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.472 |
| gyrB | polA | BB_0436 | BB_0548 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase I superfamily; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.855 |
| gyrB | recA | BB_0436 | BB_0131 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.693 |
| gyrB | topA | BB_0436 | BB_0828 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.837 |
| hrpA | BB_0826 | BB_0827 | BB_0826 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | Conserved hypothetical protein. | 0.922 |
| hrpA | BB_0830 | BB_0827 | BB_0830 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | Exonuclease SbcC; Identified by match to protein family HMM PF02463. | 0.603 |
| hrpA | leuS | BB_0827 | BB_0251 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | leucyl-tRNA synthetase; Identified by match to protein family HMM PF00133; match to protein family HMM PF08264; match to protein family HMM PF09334; match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.544 |
| hrpA | polA | BB_0827 | BB_0548 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | DNA polymerase I superfamily; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.597 |
| hrpA | sbcD | BB_0827 | BB_0829 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | Putative Exonuclease SbcD homolog; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity); Belongs to the SbcD family. | 0.760 |
| hrpA | topA | BB_0827 | BB_0828 | ATP-dependent helicase HrpA; Has RNA-stimulated ATPase activity and RNA helicase activity. Involved in global regulation of gene expression. Could be involved in RNA processing and post- transcriptional gene regulation. Essential for both tick transmission and mouse infection. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.958 |
| leuS | gyrB | BB_0251 | BB_0436 | leucyl-tRNA synthetase; Identified by match to protein family HMM PF00133; match to protein family HMM PF08264; match to protein family HMM PF09334; match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.472 |
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