node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | folD | swp_0551 | swp_3263 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | gcvT | swp_0551 | swp_0913 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.948 |
fhs | glyA | swp_0551 | swp_1337 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
fhs | purH | swp_0551 | swp_4724 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | AICARFT/IMPCHase bienzyme. | 0.990 |
fhs | purL | swp_0551 | swp_1467 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.953 |
fhs | purN | swp_0551 | swp_1817 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
fhs | purT | swp_0551 | swp_4077 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
fhs | swp_0144 | swp_0551 | swp_0144 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Oxidoreductase, short chain dehydrogenase/reductase family. | 0.902 |
fhs | swp_0992 | swp_0551 | swp_0992 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.955 |
fhs | swp_4092 | swp_0551 | swp_4092 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.926 |
folD | fhs | swp_3263 | swp_0551 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.996 |
folD | gcvT | swp_3263 | swp_0913 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.971 |
folD | glyA | swp_3263 | swp_1337 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
folD | purH | swp_3263 | swp_4724 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | AICARFT/IMPCHase bienzyme. | 0.983 |
folD | purL | swp_3263 | swp_1467 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.905 |
folD | purN | swp_3263 | swp_1817 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
folD | purT | swp_3263 | swp_4077 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.907 |
folD | swp_0992 | swp_3263 | swp_0992 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.585 |
gcvT | fhs | swp_0913 | swp_0551 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.948 |
gcvT | folD | swp_0913 | swp_3263 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |