node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hflD | hisG | swp_1862 | swp_3001 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.610 |
hflD | mnmA | swp_1862 | swp_1863 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.967 |
hflD | nudJ | swp_1862 | swp_1865 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.514 |
hflD | rnt | swp_1862 | swp_1823 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. | 0.635 |
hflD | swp_0910 | swp_1862 | swp_0910 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Conserved hypothetical protein; IPR005356, Protein of unknown function UPF0149; IPR011978, YgfB and YecA; Belongs to the UPF0149 family. | 0.629 |
hflD | swp_1860 | swp_1862 | swp_1860 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Transcription factor jumonji, jmjC. | 0.614 |
hflD | swp_1861 | swp_1862 | swp_1861 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.774 |
hflD | swp_2294 | swp_1862 | swp_2294 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Conserved hypothetical protein; IPR007840, Protein of unknown function DUF709. | 0.578 |
hflD | swp_3050 | swp_1862 | swp_3050 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | Conserved hypothetical protein; IPR003772, Protein of unknown function DUF177. | 0.701 |
hflD | truD | swp_1862 | swp_1360 | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | tRNA pseudouridine synthase D, TruD; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. | 0.543 |
hisG | hflD | swp_3001 | swp_1862 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | 0.610 |
mnmA | hflD | swp_1863 | swp_1862 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | 0.967 |
mnmA | nudJ | swp_1863 | swp_1865 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.514 |
mnmA | swp_1860 | swp_1863 | swp_1860 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Transcription factor jumonji, jmjC. | 0.618 |
mnmA | swp_1861 | swp_1863 | swp_1861 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.797 |
nudJ | hflD | swp_1865 | swp_1862 | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | 0.514 |
nudJ | mnmA | swp_1865 | swp_1863 | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.514 |
nudJ | swp_1860 | swp_1865 | swp_1860 | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | Transcription factor jumonji, jmjC. | 0.468 |
nudJ | swp_1861 | swp_1865 | swp_1861 | NUDIX hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.474 |
rnt | hflD | swp_1823 | swp_1862 | Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. | Conserved hypothetical protein; IPR007451, Protein of unknown function DUF489. | 0.635 |