node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | swp_1464 | swp_3007 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.845 |
guaA | hisB | swp_1464 | swp_3005 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.415 |
guaA | hisF | swp_1464 | swp_3008 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Histidine biosynthesis protein HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.447 |
guaA | hisH | swp_1464 | swp_3006 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.457 |
guaA | rbsK | swp_1464 | swp_3807 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Carbohydrate kinase, PfkB; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.436 |
guaA | swp_1737 | swp_1464 | swp_1737 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-guanosine kinase. | 0.939 |
hisA | guaA | swp_3007 | swp_1464 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.845 |
hisA | hisB | swp_3007 | swp_3005 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.998 |
hisA | hisC | swp_3007 | swp_3004 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.995 |
hisA | hisD | swp_3007 | swp_3003 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisF | swp_3007 | swp_3008 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidine biosynthesis protein HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | swp_3007 | swp_3001 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.996 |
hisA | hisH | swp_3007 | swp_3006 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | swp_3007 | swp_3009 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | rbsK | swp_3007 | swp_3807 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Carbohydrate kinase, PfkB; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.774 |
hisA | swp_1737 | swp_3007 | swp_1737 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Inosine-guanosine kinase. | 0.767 |
hisB | guaA | swp_3005 | swp_1464 | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.415 |
hisB | hisA | swp_3005 | swp_3007 | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.998 |
hisB | hisC | swp_3005 | swp_3004 | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | swp_3005 | swp_3003 | Histidinol-phosphatase:Histidinol-phosphate phosphatase:HAD-superfamily hydrolase, subfamily IIIA; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |