STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (271 aa)    
Predicted Functional Partners:
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
proC
Pyrroline-5-carboxylate reductase, putative; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.792
EF_1809
Transcriptional regulator, GntR family; Similar to GP:10173032, GB:X59739, GB:X59738, GB:X59740, SP:P08048, SP:P17010, PID:340434, PID:38020, PID:38022, PID:38024, GB:X59739, GB:X59738, GB:X59740, SP:P08048, SP:P17010, PID:340434, PID:38020, PID:38022, and PID:38024; identified by sequence similarity; putative.
      
 0.760
EF_0039
Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
    0.755
EF_0021
PTS system, mannose-specific IIC component; Similar to GP:5669856; identified by sequence similarity; putative.
      
 0.751
proC-2
Pyrroline-5-carboxylate reductase, putative; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.731
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
       0.522
hom
Homoserine dehydrogenase; Similar to GB:X66975, GB:X60648, GB:X65371, GB:X62006, GB:X65372, SP:P26599, PID:32354, PID:35770, PID:35772, GB:X66975, GB:X60648, GB:X65371, GB:X62006, GB:X65372, SP:P26599, PID:32354, PID:35770, and PID:35772; identified by sequence similarity; putative.
 
  
 0.492
eep
Membrane-associated zinc metalloprotease, putative; Involved in production of the peptide pheromone cAD1.
     
 0.491
EF_2986
ABC transporter, ATP-binding protein; Similar to GP:2879914, and GP:2879914; identified by sequence similarity; putative.
     
 0.477
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.