STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (315 aa)    
Predicted Functional Partners:
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
 0.999
tdK
Thymidine kinase; Similar to GB:Z24680, SP:Q14392, and PID:439296; identified by sequence similarity; putative.
  
 
 0.964
EF_0039
Deoxyuridine 5`-triphosphate nucleotidohydrolase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 0.962
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.957
EF_2448
comE operon protein 2, putative; Similar to GP:10173950, GB:M14624, and PID:177203; identified by sequence similarity; putative.
  
 
 0.942
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.942
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.934
EF_0062
Identified by match to PFAM protein family HMM PF02901.
    
 0.907
EF_1575
ABC transporter, ATP-binding protein; Identified by match to TIGR protein family HMM TIGR01193.
  
  
 0.881
EF_2928
FolC family protein; Similar to GB:X16468, GB:J00116, GB:X58709, GB:M27468, GB:X06268, GB:M63281, GB:X13783, GB:X16711, GB:X03320, GB:X02378, GB:X02376, GB:X02375, GB:X02372, GB:X02374, GB:X57010, GB:S76829, GB:U15195, GB:X02371, SP:P02458, PID:1335019, PID:1335020, PID:1335022, PID:1335023, PID:1335024, PID:180396, PID:180811, PID:29516, PID:30041, PID:30097, PID:394700, PID:529398, PID:557054, PID:562268, PID:575948, PID:673389, PID:825645, PID:930050, GB:X16468, GB:J00116, GB:X58709, GB:M27468, GB:X06268, GB:M63281, GB:X13783, GB:X16711, GB:X03320, GB:X02378, GB:X02376, GB:X02375, G [...]
     
 0.859
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.