node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EF_0905 | parE | EF_0905 | EF_1615 | Pentapeptide repeat family protein; Similar to GP:10176481; identified by sequence similarity; putative. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.573 |
EF_1610 | parC | EF_1610 | EF_1614 | Conserved domain protein. | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.620 |
EF_1610 | parE | EF_1610 | EF_1615 | Conserved domain protein. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.597 |
EF_1610 | pflA | EF_1610 | EF_1612 | Conserved domain protein. | Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | 0.774 |
EF_1610 | pflB | EF_1610 | EF_1613 | Conserved domain protein. | Formate acetyltransferase; Similar to SP:P09373, GB:X54936, GB:A18411, SP:P49763, PID:35522, and PID:512449; identified by sequence similarity; putative. | 0.740 |
EF_1610 | ppaC | EF_1610 | EF_1611 | Conserved domain protein. | Inorganic pyrophosphatase, manganese-dependent; Similar to SP:P95765, and GP:14488513; identified by sequence similarity; putative. | 0.879 |
EF_1616 | parC | EF_1616 | EF_1614 | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | 0.784 |
EF_1616 | parE | EF_1616 | EF_1615 | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.805 |
EF_1616 | pflA | EF_1616 | EF_1612 | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | 0.519 |
EF_1616 | pflB | EF_1616 | EF_1613 | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | Formate acetyltransferase; Similar to SP:P09373, GB:X54936, GB:A18411, SP:P49763, PID:35522, and PID:512449; identified by sequence similarity; putative. | 0.508 |
EF_1616 | plsY | EF_1616 | EF_1643 | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | Conserved hypothetical protein TIGR00023; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.646 |
dnaN | parE | EF_0002 | EF_1615 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.570 |
gyrA | parE | EF_0006 | EF_1615 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.993 |
parC | EF_1610 | EF_1614 | EF_1610 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | Conserved domain protein. | 0.620 |
parC | EF_1616 | EF_1614 | EF_1616 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | CoA-binding domain protein; Similar to GP:10174760; identified by sequence similarity; putative. | 0.784 |
parC | parE | EF_1614 | EF_1615 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. | 0.999 |
parC | pflA | EF_1614 | EF_1612 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | 0.761 |
parC | pflB | EF_1614 | EF_1613 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | Formate acetyltransferase; Similar to SP:P09373, GB:X54936, GB:A18411, SP:P49763, PID:35522, and PID:512449; identified by sequence similarity; putative. | 0.781 |
parC | plsY | EF_1614 | EF_1643 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | Conserved hypothetical protein TIGR00023; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.662 |
parC | ppaC | EF_1614 | EF_1611 | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. | Inorganic pyrophosphatase, manganese-dependent; Similar to SP:P95765, and GP:14488513; identified by sequence similarity; putative. | 0.724 |