node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EF_1720 | pyrB | EF_1720 | EF_1719 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.992 |
EF_1720 | pyrC | EF_1720 | EF_1718 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.984 |
EF_1720 | pyrD-2 | EF_1720 | EF_1714 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. | 0.885 |
EF_1720 | pyrDII | EF_1720 | EF_1715 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.881 |
EF_1720 | pyrE | EF_1720 | EF_1712 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.940 |
EF_1720 | pyrF | EF_1720 | EF_1713 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.939 |
EF_1720 | pyrR | EF_1720 | EF_1721 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Pyrimidine operon regulatory protein PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, by binding to the anti-antiterminator region of the 5' leader on pyr mRNA. This probably favors formation of a transcription terminator hairpin, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.986 |
EF_1720 | pyraA | EF_1720 | EF_1717 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Carbamoyl-phosphate synthase, small subunit; Similar to GP:7688228, and SP:P25993; identified by sequence similarity; putative; Belongs to the CarA family. | 0.981 |
EF_1720 | pyraB | EF_1720 | EF_1716 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Carbamoyl-phosphate synthase, large subunit; Similar to GP:2598551, and SP:P25994; identified by sequence similarity; putative. | 0.979 |
EF_1720 | upp | EF_1720 | EF_2549 | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.500 |
pyrB | EF_1720 | EF_1719 | EF_1720 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil permease; Similar to GP:2895752, and SP:P39766; identified by sequence similarity; putative. | 0.992 |
pyrB | pyrC | EF_1719 | EF_1718 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrD-2 | EF_1719 | EF_1714 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. | 0.979 |
pyrB | pyrDII | EF_1719 | EF_1715 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.988 |
pyrB | pyrE | EF_1719 | EF_1712 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.993 |
pyrB | pyrF | EF_1719 | EF_1713 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.993 |
pyrB | pyrR | EF_1719 | EF_1721 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Pyrimidine operon regulatory protein PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, by binding to the anti-antiterminator region of the 5' leader on pyr mRNA. This probably favors formation of a transcription terminator hairpin, leading to a reduced expression of downstream genes (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.997 |
pyrB | pyraA | EF_1719 | EF_1717 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoyl-phosphate synthase, small subunit; Similar to GP:7688228, and SP:P25993; identified by sequence similarity; putative; Belongs to the CarA family. | 0.999 |
pyrB | pyraB | EF_1719 | EF_1716 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoyl-phosphate synthase, large subunit; Similar to GP:2598551, and SP:P25994; identified by sequence similarity; putative. | 0.999 |
pyrB | upp | EF_1719 | EF_2549 | Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.585 |