STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
 
 0.999
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
 0.999
EF_1861
Conserved domain protein; Similar to GB:L29436, and PID:459904; identified by sequence similarity; putative.
 
   
 0.942
EF_0517
2-dehydropantoate 2-reductase, putative; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.918
EF_1655
2-dehydropantoate 2-reductase, putative; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.918
EF_2445
2-dehydropantoate 2-reductase, putative; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.918
coaA
Pantothenate kinase, putative; Similar to GB:L23958, SP:Q14204, PID:1314643, PID:1549349, and PID:397774; identified by sequence similarity; putative.
     
 0.916
cmk
Cytidylate kinase; Similar to GB:X56351, SP:P13196, and PID:28583; identified by sequence similarity; putative.
      0.908
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
   
 
 0.859
EF_2655
Flavoprotein-related protein; Similar to SP:P21324, and PID:145151; identified by sequence similarity; putative.
  
 
 0.850
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.