STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; Similar to SP:P12047; identified by sequence similarity; putative; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.997
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
 
 
 0.995
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.988
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to SP:P12048; identified by sequence similarity; putative.
  
 0.985
hpt
Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:K00558, GB:S62639, SP:P04687, SP:P05215, PID:340019, PID:340021, and PID:37492; identified by sequence similarity; putative.
  
 
 0.942
pyrB
Aspartate carbamoyltransferase; Similar to SP:P05654; identified by sequence similarity; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.938
EF_1037
L-aspartate beta-decarboxylase, putative; Similar to GP:14279103; identified by sequence similarity; putative.
  
 0.914
EF_0062
Identified by match to PFAM protein family HMM PF02901.
    
 0.911
EF_1163
L-asparaginase, putative; Similar to GP:10174241; identified by sequence similarity; putative.
  
  
  0.911
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.901
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.