STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsHPhosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain (88 aa)    
Predicted Functional Partners:
ptsI
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
 
 
 0.997
ccpA
Catabolite control protein A; Similar to GP:3676165, and GP:3676165; identified by sequence similarity; putative
   
 
 0.993
EF_0717
PTS system, fructose-specific family, IIABC components; Identified by match to PFAM protein family HMM PF02653
 
 
 0.930
hprK
HPr kinase/phosphorylase; Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carb [...]
 
 
 
 0.925
EF_0958
PTS system, IIABC components; Similar to GP:4098489; identified by sequence similarity; putative
 
 
 0.919
EF_1516
PTS system, IIABC components; Similar to GB:X54994, SP:P12731, and PID:40106; identified by sequence similarity; putative
 
 
 0.919
EF_0020
PTS system, mannose-specific IIAB components; Similar to GP:5669855, and GP:5669855; identified by sequence similarity; putative
  
 
 0.916
EF_1601
PTS system, IIABC components; Similar to PIR:S68599; identified by sequence similarity; putative
 
 
 0.914
EF_0270
PTS system, beta-glucoside-specific IIABC component; Similar to GB:X65867, GB:S60710, SP:P30566, PID:28904, PID:28905, GB:U07449, SP:P01621, SP:P04433, PID:470434, PID:470562, PID:470592, PID:470596, PID:470602, PID:470606, PID:470608, PID:470612, PID:553478, PID:560766, PID:567140, PID:619617, PID:619761, PID:722482, PID:722494, PID:722498, PID:722510, PID:722596, PID:722604, PID:762824, PID:809555, PID:845516, PID:845524, PID:845528, PID:860994, PID:861002, and PID:871276; identified by sequence similarity; putative
  
 
 0.900
EF_0694
PTS system, fructose-specific family, IIBC components; Similar to GP:10173443; identified by sequence similarity; putative
  
 
 0.900
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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