STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
vanHBD-specific alpha-keto acid dehydrogenase; Required for high-level resistance to glycopeptides antibiotics. Catalyzes the reduction of 2-keto acids to 2-D-hydroxy acids that give rise to peptidoglycan precursors that terminate in the depsipeptide D-alanine-2-lactate rather than the dipeptide D-alanine-D- alanine thus preventing vancomycin binding; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)    
Predicted Functional Partners:
vanX
D-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. Belongs to the peptidase M15D family.
 
   
 0.981
vanB
D-alanine--D-lactate ligase; Required for high-level resistance to glycopeptides antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin binding.
 
  
 0.979
vanYB
D-alanyl-D-alanine carboxypeptidase; Carboxypeptidase that cleaves the C-terminal D-alanine residue from the peptidoglycan-derived pentapeptide L-Ala-gamma-D-Glu- L-Lys-D-Ala-D-Ala in vitro. Therefore, should contribute in vivo to the hydrolysis of the D-alanyl-D-alanine-containing peptidoglycan precursors. May increase the level of glycopeptide antibiotics resistance by decreasing the availability of D-Ala-D-Ala termini from the cell surface, which constitute the antibiotic target residues.
 
   
 0.951
vanSB
Sensor histidine kinase VanSB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates VanR by phosphorylation.
 
  
 0.905
vanW
Vancomycin B-type resistance protein VanW; Similar to GB:M94362, GB:M94363, SP:Q03252, PID:1054874, GB:M94362, GB:M94363, SP:Q03252, and PID:1054874; identified by sequence similarity; putative.
     
 0.872
vanRB
DNA-binding response regulator VanRB; Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance.
  
  
 0.697
pyk
Pyruvate kinase; Identified by match to PFAM protein family HMM PF02629; Belongs to the pyruvate kinase family.
  
 
 0.691
gpm
Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
 
  
 0.650
cinA
Competence/damage-inducible protein CinA; Similar to GP:1842440, SP:Q04730, and PID:142946; identified by sequence similarity; putative; Belongs to the CinA family.
  
    0.589
EF_2292
Identified by match to TIGR protein family HMM TIGR01519.
       0.565
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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