STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EF_3068Conserved hypothetical protein; Similar to GP:4584089, and GP:4584089; identified by sequence similarity; putative. (217 aa)    
Predicted Functional Partners:
EF_3067
Hydrolase, haloacid dehalogenase-like family; Identified by match to TIGR protein family HMM TIGR01681.
       0.884
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.603
EF_3069
Formate/nitrite transporter family protein; Similar to GP:4433636; identified by sequence similarity; putative.
       0.581
EF_2503
Conserved domain protein; Similar to GP:153733; identified by sequence similarity; putative.
  
     0.510
EF_3177
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.493
fpg
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
     
 0.465
mutY
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
      
 0.459
EF_1228
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.455
htrA
Serine protease DO; Similar to GP:7363330, and GP:7363330; identified by sequence similarity; putative.
  
    0.442
EF_2785
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.422
Your Current Organism:
Enterococcus faecalis V583
NCBI taxonomy Id: 226185
Other names: E. faecalis V583, Enterococcus faecalis str. V583, Enterococcus faecalis strain V583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.