node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BT_4592 | SecG | BT_4592 | BT_4378 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.937 |
BT_4592 | ffh | BT_4592 | BT_1601 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Putative signal recognition protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.928 |
BT_4592 | ftsY | BT_4592 | BT_0914 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.929 |
BT_4592 | secA | BT_4592 | BT_4362 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. | 0.935 |
BT_4592 | secD | BT_4592 | BT_2835 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Protein-export membrane protein SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.994 |
BT_4592 | secY | BT_4592 | BT_2707 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.946 |
BT_4592 | yidC | BT_4592 | BT_0589 | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.938 |
RnpA | SecG | BT_3227 | BT_4378 | Putative ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.587 |
RnpA | rho | BT_3227 | BT_1595 | Putative ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.770 |
RnpA | secD | BT_3227 | BT_2835 | Putative ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Protein-export membrane protein SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.412 |
RnpA | yidC | BT_3227 | BT_0589 | Putative ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.898 |
SecG | BT_4592 | BT_4378 | BT_4592 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | 0.937 |
SecG | RnpA | BT_4378 | BT_3227 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Putative ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.587 |
SecG | ffh | BT_4378 | BT_1601 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Putative signal recognition protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.979 |
SecG | ftsY | BT_4378 | BT_0914 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.980 |
SecG | secA | BT_4378 | BT_4362 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. | 0.996 |
SecG | secD | BT_4378 | BT_2835 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein-export membrane protein SecD/SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.995 |
SecG | secY | BT_4378 | BT_2707 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.995 |
SecG | yidC | BT_4378 | BT_0589 | Putative protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.985 |
ffh | BT_4592 | BT_1601 | BT_4592 | Putative signal recognition protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Conserved hypothetical protein with conserved domain; Putative preprotein translocase subunit, YajC-like. | 0.928 |