node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BT_0832 | BT_2341 | BT_0832 | BT_2341 | Putative phosphoserine phosphatase. | Conserved hypothetical protein. | 0.604 |
BT_0832 | hisA | BT_0832 | BT_1379 | Putative phosphoserine phosphatase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.703 |
BT_0832 | hisB | BT_0832 | BT_0203 | Putative phosphoserine phosphatase. | Histidine biosynthesis bifunctional protein hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.890 |
BT_0832 | hisC | BT_0832 | BT_0202 | Putative phosphoserine phosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.646 |
BT_0832 | hisD | BT_0832 | BT_0201 | Putative phosphoserine phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.693 |
BT_0832 | hisF | BT_0832 | BT_1378 | Putative phosphoserine phosphatase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.796 |
BT_0832 | hisG | BT_0832 | BT_0200 | Putative phosphoserine phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.490 |
BT_0832 | hisH | BT_0832 | BT_1380 | Putative phosphoserine phosphatase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.713 |
BT_0832 | hisI | BT_0832 | BT_1377 | Putative phosphoserine phosphatase. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.957 |
BT_2341 | BT_0832 | BT_2341 | BT_0832 | Conserved hypothetical protein. | Putative phosphoserine phosphatase. | 0.604 |
BT_2341 | hisA | BT_2341 | BT_1379 | Conserved hypothetical protein. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.896 |
BT_2341 | hisB | BT_2341 | BT_0203 | Conserved hypothetical protein. | Histidine biosynthesis bifunctional protein hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.914 |
BT_2341 | hisC | BT_2341 | BT_0202 | Conserved hypothetical protein. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.799 |
BT_2341 | hisD | BT_2341 | BT_0201 | Conserved hypothetical protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.909 |
BT_2341 | hisF | BT_2341 | BT_1378 | Conserved hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.906 |
BT_2341 | hisG | BT_2341 | BT_0200 | Conserved hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.965 |
BT_2341 | hisH | BT_2341 | BT_1380 | Conserved hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.890 |
BT_2341 | hisI | BT_2341 | BT_1377 | Conserved hypothetical protein. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.961 |
BT_2434 | hisA | BT_2434 | BT_1379 | Pyridine nucleotide-disulphide oxidoreductase; Belongs to the sulfur carrier protein TusA family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.445 |
BT_2434 | hisB | BT_2434 | BT_0203 | Pyridine nucleotide-disulphide oxidoreductase; Belongs to the sulfur carrier protein TusA family. | Histidine biosynthesis bifunctional protein hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.401 |