node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BC_4439 | cshA | BC_4439 | BC_0259 | Ribonuclease G. | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | 0.582 |
BC_4439 | pnp | BC_4439 | BC_3805 | Ribonuclease G. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.917 |
BC_4439 | rho | BC_4439 | BC_5332 | Ribonuclease G. | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.522 |
cshA | BC_4439 | BC_0259 | BC_4439 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | Ribonuclease G. | 0.582 |
cshA | infB | BC_0259 | BC_3811 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.405 |
cshA | nusA | BC_0259 | BC_3814 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.467 |
cshA | pnp | BC_0259 | BC_3805 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.991 |
cshA | pyrG | BC_0259 | BC_5338 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.787 |
cshA | rho | BC_0259 | BC_5332 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.571 |
cshA | rny | BC_0259 | BC_3778 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | Hydrolase (HAD superfamily); Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.935 |
cshA | rplC | BC_0259 | BC_0131 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.842 |
cshA | rpoB | BC_0259 | BC_0122 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.617 |
cshA | rpsO | BC_0259 | BC_3806 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | SSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.693 |
infB | cshA | BC_3811 | BC_0259 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with cshB, as cshA can partially complement the growth effects of a cshB deletion. Plays a role in adaptation to cold, oxididant and pH stress. | 0.405 |
infB | nusA | BC_3811 | BC_3814 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.996 |
infB | pnp | BC_3811 | BC_3805 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.921 |
infB | pyrG | BC_3811 | BC_5338 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.844 |
infB | rho | BC_3811 | BC_5332 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.739 |
infB | rplC | BC_3811 | BC_0131 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.987 |
infB | rpoB | BC_3811 | BC_0122 | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.970 |