node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BC_0466 | gcvPA | BC_0466 | BC_4225 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.696 |
BC_0466 | gcvPB | BC_0466 | BC_4224 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.923 |
BC_0466 | glyA | BC_0466 | BC_5316 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.484 |
BC_0466 | lpdA | BC_0466 | BC_2776 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Dihydrolipoamide dehydrogenase. | 0.416 |
BC_0466 | lpdA-2 | BC_0466 | BC_3970 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Dihydrolipoamide dehydrogenase. | 0.420 |
BC_0466 | lpdA-3 | BC_0466 | BC_4160 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Dihydrolipoamide dehydrogenase. | 0.416 |
BC_0621 | BC_2839 | BC_0621 | BC_2839 | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Sarcosine oxidase alpha subunit. | 0.900 |
BC_0621 | gcvPA | BC_0621 | BC_4225 | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.942 |
BC_0621 | gcvPB | BC_0621 | BC_4224 | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.938 |
BC_0621 | gcvT | BC_0621 | BC_4226 | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.642 |
BC_0621 | glyA | BC_0621 | BC_5316 | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
BC_2839 | BC_0621 | BC_2839 | BC_0621 | Sarcosine oxidase alpha subunit. | 2-amino-3-ketobutyrate coenzyme A ligase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
BC_2839 | gcvPA | BC_2839 | BC_4225 | Sarcosine oxidase alpha subunit. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.908 |
BC_2839 | gcvPB | BC_2839 | BC_4224 | Sarcosine oxidase alpha subunit. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.908 |
BC_2839 | glyA | BC_2839 | BC_5316 | Sarcosine oxidase alpha subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
BC_2839 | lpdA | BC_2839 | BC_2776 | Sarcosine oxidase alpha subunit. | Dihydrolipoamide dehydrogenase. | 0.593 |
BC_2839 | lpdA-2 | BC_2839 | BC_3970 | Sarcosine oxidase alpha subunit. | Dihydrolipoamide dehydrogenase. | 0.593 |
BC_2839 | lpdA-3 | BC_2839 | BC_4160 | Sarcosine oxidase alpha subunit. | Dihydrolipoamide dehydrogenase. | 0.593 |
gcvH | gcvPA | BC_4991 | BC_4225 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.998 |
gcvH | gcvPB | BC_4991 | BC_4224 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Glycine dehydrogenase, decarboxylating; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |