STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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aflRSterigmatocystin biosynthesis regulatory protein; Involved in the regulation of sterigmatocystin biosynthesis. (433 aa)    
Predicted Functional Partners:
laeA
Secondary metabolism regulator laeA; Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondar [...]
      
 0.913
veA
Developmental and secondary metabolism regulator veA; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin and penicillin gene clusters. Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner. Required for full induct [...]
      
 0.903
stcU
Versicolorin reductase; Catalyzes the conversion of versicolorin A to sterigmatocystin; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.765
velB
Velvet complex subunit B; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination. The velvet complex acts as a global regulator for secondary metabolite gene expression. Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes. The velB-VosA complex binds DNA through the DNA-binding domain of vosA th [...]
      
 0.663
brlA
C2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'- (C/A)(A/G)AGGG(G/A)-3'. Controls the expression of the conidiophore-specific phenol oxidase ivoB. Controls the expression of the hydrophobin rodA. Mediates the developmental switch from the indeterminate, apic [...]
   
  
 0.641
ipnA
Isopenicillin N synthase; Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin.
      
 0.608
tdiB
Indole prenyltransferase tdiB; Indole prenyltransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent. The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD. TdiA then immediately converts unstable IDA to didemethylasterriquinone D (DDAQ D). TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1. Finally, tdiC and tdiE enzymes robustly convert asterriquinone C [...]
      
 0.584
mdpA
Monodictyphenone cluster transcriptional coactivator mdpA; Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative. With mdpE, coregulates the production of monodictyphenone.
  
   
 0.444
pyrG
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.
      
 0.422
nsdD
GATA-type domain-containing protein.
      
 0.418
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 227321
Other names: A. nidulans FGSC A4, Aspergillus nidulans FGSC A4, Emericella nidulans FGSC A4
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