node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HNE_1940 | HNE_2722 | HNE_1940 | HNE_2722 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | 0.907 |
HNE_1940 | gcvPA | HNE_1940 | HNE_2721 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Glycine cleavage system P-protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.904 |
HNE_1940 | gcvT | HNE_1940 | HNE_2719 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.595 |
HNE_1940 | gltB | HNE_1940 | HNE_0093 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Glutamate synthase, large subunit; Identified by similarity to SP:Q05755; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.459 |
HNE_1940 | glyA | HNE_1940 | HNE_2060 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
HNE_1940 | hemA | HNE_1940 | HNE_2062 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | 5-aminolevulinic acid synthase; Identified by similarity to SP:Q04512; match to protein family HMM PF00155; match to protein family HMM TIGR01821. | 0.905 |
HNE_1940 | ltaE | HNE_1940 | HNE_0475 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | Threonine aldolase, low-specificity; Identified by similarity to SP:O50584; match to protein family HMM PF01212. | 0.904 |
HNE_2722 | HNE_1940 | HNE_2722 | HNE_1940 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266. | 0.907 |
HNE_2722 | gcvH | HNE_2722 | HNE_2720 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
HNE_2722 | gcvPA | HNE_2722 | HNE_2721 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Glycine cleavage system P-protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
HNE_2722 | gcvT | HNE_2722 | HNE_2719 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.999 |
HNE_2722 | gltB | HNE_2722 | HNE_0093 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Glutamate synthase, large subunit; Identified by similarity to SP:Q05755; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.901 |
HNE_2722 | glyA | HNE_2722 | HNE_2060 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
HNE_2722 | hemA | HNE_2722 | HNE_2062 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | 5-aminolevulinic acid synthase; Identified by similarity to SP:Q04512; match to protein family HMM PF00155; match to protein family HMM TIGR01821. | 0.913 |
HNE_2722 | lpdA1 | HNE_2722 | HNE_1974 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.926 |
HNE_2722 | lpdA2 | HNE_2722 | HNE_3262 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.926 |
HNE_2722 | ltaE | HNE_2722 | HNE_0475 | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | Threonine aldolase, low-specificity; Identified by similarity to SP:O50584; match to protein family HMM PF01212. | 0.923 |
gcvH | HNE_2722 | HNE_2720 | HNE_2722 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 2; Identified by match to protein family HMM PF02347. | 0.999 |
gcvH | gcvPA | HNE_2720 | HNE_2721 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
gcvH | gcvT | HNE_2720 | HNE_2719 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.999 |