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recA protein (Hyphomonas neptunium) - STRING interaction network
recA protein in Hyphomonas neptunium
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (356 aa)    
Predicted Functional Partners:
HNE_2532
ATP-dependent DNA helicase domain-containing protein (1715 aa)
   
  0.992
polA
DNA polymerase I (929 aa)
   
  0.987
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (227 aa)
   
 
  0.980
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (634 aa)
   
  0.975
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3’-5’ exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (424 aa)
   
  0.957
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (890 aa)
   
  0.945
HNE_2465
Hypothetical protein (521 aa)
   
  0.936
recQ
ATP-dependent DNA helicase RecQ (615 aa)
     
  0.931
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (926 aa)
   
 
  0.918
dnaN
DNA polymerase III subunit beta; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (373 aa)
   
  0.918
Your Current Organism:
Hyphomonas neptunium
NCBI taxonomy Id: 228405
Other names: H. neptunium, H. neptunium ATCC 15444, Hyphomicrobium neptunium, Hyphomonas, Hyphomonas neptunium, Hyphomonas neptunium ATCC 15444, Hyphomonas neptunium str. ATCC 15444, Hyphomonas neptunium strain ATCC 15444
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