STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (181 aa)    
Predicted Functional Partners:
ruvA
Probable Holliday junction DNA helicase subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 
 0.996
ruvB
ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.985
NE0210
Domain of unknown function DUF28.
  
  
 0.877
polA
polA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.718
NE0214
4-hydroxybenzoyl-CoA thioesterase family active site.
 
   
 0.689
tolQ
MotA/TolQ/ExbB proton channel family; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
       0.636
tolR
Biopolymer transport protein ExbD/TolR.
       0.634
glmS
Glutamine amidotransferase class-II:SIS domain; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
     
 0.609
NE1203
Similar to (AF145800) immunogenic 75 kDa protein PG4 [Porphyromonas gingivalis], evalue=8.00e-07, 24% identity.
     
 0.595
NE1761
Hypothetical protein; InterPro IPR001687.
     
 0.595
Your Current Organism:
Nitrosomonas europaea
NCBI taxonomy Id: 228410
Other names: N. europaea ATCC 19718, Nitrosomonas europaea ATCC 19718, Nitrosomonas europaea str. ATCC 19718
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