node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE0592 | cysG | NE0592 | NE0532 | Possible uroporphyrin-III C-methyltransferase. | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.910 |
NE0592 | hemC | NE0592 | NE0590 | Possible uroporphyrin-III C-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.811 |
NE0592 | hemD | NE0592 | NE0591 | Possible uroporphyrin-III C-methyltransferase. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.990 |
NE0592 | hemE | NE0592 | NE0445 | Possible uroporphyrin-III C-methyltransferase. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.903 |
NE1539 | NE2303 | NE1539 | NE2303 | Hypothetical protein. | Uncharacterized NAD(FAD)-dependent dehydrogenases. | 0.715 |
NE1539 | cysG | NE1539 | NE0532 | Hypothetical protein. | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.992 |
NE1539 | hemD | NE1539 | NE0591 | Hypothetical protein. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.459 |
NE1539 | yvgQ | NE1539 | NE0852 | Hypothetical protein. | Nitrite and sulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.408 |
NE2303 | NE1539 | NE2303 | NE1539 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Hypothetical protein. | 0.715 |
NE2303 | cysD | NE2303 | NE0856 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Phosphoadenosine phosphosulfate reductase. | 0.429 |
NE2303 | cysG | NE2303 | NE0532 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.991 |
NE2303 | cysH | NE2303 | NE0855 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Probable cysH; Reduction of activated sulfate into sulfite. | 0.440 |
NE2303 | hemC | NE2303 | NE0590 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.576 |
NE2303 | hemD | NE2303 | NE0591 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.688 |
NE2303 | hemE | NE2303 | NE0445 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.468 |
NE2303 | yvgQ | NE2303 | NE0852 | Uncharacterized NAD(FAD)-dependent dehydrogenases. | Nitrite and sulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.563 |
NE2457 | cysG | NE2457 | NE0532 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.923 |
NE2457 | hemC | NE2457 | NE0590 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
NE2457 | hemD | NE2457 | NE0591 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.907 |
NE2457 | hemE | NE2457 | NE0445 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.782 |