STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)    
Predicted Functional Partners:
NE1951
Fumarate lyase:Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.996
guaB
guaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.988
purL
AIR synthase related protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.987
purH
Imilar to (NC_003295) PROBABLE BIFUNCTIONAL: PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE AND IMP CYCLOHYDROLASE TRANSMEMBRANE PROTEIN [Ralstonia solanacearum] evalue=0.00e+00, 65% identity.
  
 0.979
pyrB
pyrB; aspartate carbamoyltransferase (catalytic chain) protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.940
argG
Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
   
 
 0.939
guaA
guaA; Catalyzes the synthesis of GMP from XMP.
 
  
 0.920
nadB1
nadB1; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.912
NE1795
Glutamine amidotransferase class-II:Asparagine synthase.
   
 
 0.911
aatA
Aminotransferases class-I; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate, with lower efficiency.
   
 0.910
Your Current Organism:
Nitrosomonas europaea
NCBI taxonomy Id: 228410
Other names: N. europaea ATCC 19718, Nitrosomonas europaea ATCC 19718, Nitrosomonas europaea str. ATCC 19718
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