node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE2457 | cysG | NE2457 | NE0532 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.923 |
NE2457 | guaA | NE2457 | NE0094 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | guaA; Catalyzes the synthesis of GMP from XMP. | 0.416 |
NE2457 | hemA | NE2457 | NE1914 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.883 |
NE2457 | hemC | NE2457 | NE0590 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
NE2457 | hemD | NE2457 | NE0591 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.907 |
NE2457 | hemE | NE2457 | NE0445 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.782 |
NE2457 | hemL | NE2457 | NE1423 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | hemL; glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.993 |
NE2457 | rkpA | NE2457 | NE1389 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. | 0.558 |
cysG | NE2457 | NE0532 | NE2457 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.923 |
cysG | hemA | NE0532 | NE1914 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.850 |
cysG | hemC | NE0532 | NE0590 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |
cysG | hemD | NE0532 | NE0591 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.992 |
cysG | hemE | NE0532 | NE0445 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.964 |
cysG | hemL | NE0532 | NE1423 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | hemL; glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.794 |
cysG | thiD | NE0532 | NE1425 | cysG_2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative phosphomethylpyrimidine kinase. | 0.414 |
guaA | NE2457 | NE0094 | NE2457 | guaA; Catalyzes the synthesis of GMP from XMP. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.416 |
guaA | hemE | NE0094 | NE0445 | guaA; Catalyzes the synthesis of GMP from XMP. | Uroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.489 |
guaA | hemL | NE0094 | NE1423 | guaA; Catalyzes the synthesis of GMP from XMP. | hemL; glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.598 |
guaA | rkpA | NE0094 | NE1389 | guaA; Catalyzes the synthesis of GMP from XMP. | Similar to (AF285636) putative type I polyketide synthase WcbR [Burkholderia mallei], evalue=0.00e+00, 41% identity. | 0.528 |
guaA | thiD | NE0094 | NE1425 | guaA; Catalyzes the synthesis of GMP from XMP. | Putative phosphomethylpyrimidine kinase. | 0.461 |