node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argA | nadK | NE0778 | NE1478 | GCN5-related N-acetyltransferase:Aspartokinase superfamily; Belongs to the acetyltransferase family. ArgA subfamily. | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.545 |
dxs | nadE | NE1161 | NE1896 | Transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.539 |
dxs | nadK | NE1161 | NE1478 | Transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.693 |
hrcA | nadK | NE1477 | NE1478 | Negative regulator of class I heat shock protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.572 |
hrcA | recN | NE1477 | NE1479 | Negative regulator of class I heat shock protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | ABC transporter:DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.631 |
nadD | nadE | NE0359 | NE1896 | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.965 |
nadD | nadK | NE0359 | NE1478 | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.943 |
nadD | pntAa | NE0359 | NE0859 | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Alanine dehydrogenase and pyridine nucleotide transhydrogenase. | 0.901 |
nadD | pntAb2 | NE0359 | NE0860 | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Similar to (NC_003296) PROBABLE TRANSMEMBRANE NAD(P) TRANSHYDROGENASE (ALPHA SUBUNIT PART 2) TRANSMEMBRANE PROTEIN [Ralstonia solanacearum] evalue=6.00e-34, 69% identity. | 0.901 |
nadD | pntB | NE0359 | NE0861 | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
nadE | dxs | NE1896 | NE1161 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.539 |
nadE | nadD | NE1896 | NE0359 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.965 |
nadE | nadK | NE1896 | NE1478 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.960 |
nadE | pntAa | NE1896 | NE0859 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Alanine dehydrogenase and pyridine nucleotide transhydrogenase. | 0.905 |
nadE | pntAb2 | NE1896 | NE0860 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Similar to (NC_003296) PROBABLE TRANSMEMBRANE NAD(P) TRANSHYDROGENASE (ALPHA SUBUNIT PART 2) TRANSMEMBRANE PROTEIN [Ralstonia solanacearum] evalue=6.00e-34, 69% identity. | 0.905 |
nadE | pntB | NE1896 | NE0861 | Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.940 |
nadK | argA | NE1478 | NE0778 | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | GCN5-related N-acetyltransferase:Aspartokinase superfamily; Belongs to the acetyltransferase family. ArgA subfamily. | 0.545 |
nadK | dxs | NE1478 | NE1161 | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.693 |
nadK | hrcA | NE1478 | NE1477 | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Negative regulator of class I heat shock protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.572 |
nadK | nadD | NE1478 | NE0359 | Domain of unknown function DUF15; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Cytidylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.943 |