node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NE1155 | NE1444 | NE1155 | NE1444 | DnaJ N-terminal domain:DnaJ C terminal domain. | TPR repeat. | 0.898 |
NE1155 | clpA | NE1155 | NE1733 | DnaJ N-terminal domain:DnaJ C terminal domain. | ClpA, ATP dependent protease, chaperonin; Belongs to the ClpA/ClpB family. | 0.686 |
NE1155 | clpB | NE1155 | NE2402 | DnaJ N-terminal domain:DnaJ C terminal domain. | ClpB ATPase dependent protease, chaperonin; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ [...] | 0.686 |
NE1155 | dnaK | NE1155 | NE1949 | DnaJ N-terminal domain:DnaJ C terminal domain. | Heat shock protein hsp70, molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
NE1155 | groEL | NE1155 | NE0028 | DnaJ N-terminal domain:DnaJ C terminal domain. | TCP-1 (Tailless complex polypeptide)/cpn60 chaparonin family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.714 |
NE1155 | groES | NE1155 | NE0027 | DnaJ N-terminal domain:DnaJ C terminal domain. | Chaperonins cpn10 (10 Kd subunit); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.640 |
NE1155 | grpE | NE1155 | NE1950 | DnaJ N-terminal domain:DnaJ C terminal domain. | GrpE protein, molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.938 |
NE1155 | hptG | NE1155 | NE1762 | DnaJ N-terminal domain:DnaJ C terminal domain. | Probable hptG; Molecular chaperone. Has ATPase activity. | 0.963 |
NE1155 | hrcA | NE1155 | NE1477 | DnaJ N-terminal domain:DnaJ C terminal domain. | Negative regulator of class I heat shock protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.671 |
NE1444 | NE1155 | NE1444 | NE1155 | TPR repeat. | DnaJ N-terminal domain:DnaJ C terminal domain. | 0.898 |
NE1444 | clpA | NE1444 | NE1733 | TPR repeat. | ClpA, ATP dependent protease, chaperonin; Belongs to the ClpA/ClpB family. | 0.670 |
NE1444 | clpB | NE1444 | NE2402 | TPR repeat. | ClpB ATPase dependent protease, chaperonin; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ [...] | 0.670 |
NE1444 | dnaJ | NE1444 | NE1948 | TPR repeat. | DnaJ molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.897 |
NE1444 | dnaK | NE1444 | NE1949 | TPR repeat. | Heat shock protein hsp70, molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
NE1444 | groEL | NE1444 | NE0028 | TPR repeat. | TCP-1 (Tailless complex polypeptide)/cpn60 chaparonin family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.525 |
NE1444 | groES | NE1444 | NE0027 | TPR repeat. | Chaperonins cpn10 (10 Kd subunit); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.557 |
NE1444 | grpE | NE1444 | NE1950 | TPR repeat. | GrpE protein, molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.538 |
NE1444 | hptG | NE1444 | NE1762 | TPR repeat. | Probable hptG; Molecular chaperone. Has ATPase activity. | 0.970 |
clpA | NE1155 | NE1733 | NE1155 | ClpA, ATP dependent protease, chaperonin; Belongs to the ClpA/ClpB family. | DnaJ N-terminal domain:DnaJ C terminal domain. | 0.686 |
clpA | NE1444 | NE1733 | NE1444 | ClpA, ATP dependent protease, chaperonin; Belongs to the ClpA/ClpB family. | TPR repeat. | 0.670 |