node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ajs_0639 | Ajs_2202 | Ajs_0639 | Ajs_2202 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | 0.873 |
Ajs_0639 | groL | Ajs_0639 | Ajs_0699 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.828 |
Ajs_0639 | grpE | Ajs_0639 | Ajs_3217 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.956 |
Ajs_0639 | hscA | Ajs_0639 | Ajs_2140 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.855 |
Ajs_0639 | htpG | Ajs_0639 | Ajs_0475 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.873 |
Ajs_2139 | Ajs_2143 | Ajs_2139 | Ajs_2143 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: pol:Bpro_2183 ferredoxin, 2Fe-2S type. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.983 |
Ajs_2139 | hscA | Ajs_2139 | Ajs_2140 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: pol:Bpro_2183 ferredoxin, 2Fe-2S type. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.957 |
Ajs_2139 | hscB | Ajs_2139 | Ajs_2141 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: pol:Bpro_2183 ferredoxin, 2Fe-2S type. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
Ajs_2139 | iscS | Ajs_2139 | Ajs_2144 | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: pol:Bpro_2183 ferredoxin, 2Fe-2S type. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.979 |
Ajs_2143 | Ajs_2139 | Ajs_2143 | Ajs_2139 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: pol:Bpro_2183 ferredoxin, 2Fe-2S type. | 0.983 |
Ajs_2143 | hscA | Ajs_2143 | Ajs_2140 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.929 |
Ajs_2143 | hscB | Ajs_2143 | Ajs_2141 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.997 |
Ajs_2143 | iscS | Ajs_2143 | Ajs_2144 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.999 |
Ajs_2202 | Ajs_0639 | Ajs_2202 | Ajs_0639 | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: eba:ebA2728 curved DNA-binding protein. | 0.873 |
Ajs_2202 | dnaJ | Ajs_2202 | Ajs_3219 | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.873 |
Ajs_2202 | groL | Ajs_2202 | Ajs_0699 | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.866 |
Ajs_2202 | grpE | Ajs_2202 | Ajs_3217 | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.752 |
Ajs_2202 | hscA | Ajs_2202 | Ajs_2140 | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.830 |
dnaJ | Ajs_2202 | Ajs_3219 | Ajs_2202 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | DNA mismatch repair enzyme (predicted ATPase)-like protein; KEGG: nma:NMA0428 hypothetical protein. | 0.873 |
dnaJ | groL | Ajs_3219 | Ajs_0699 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.951 |