node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acid_0002 | Acid_1665 | Acid_0002 | Acid_1665 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.870 |
Acid_0002 | dut | Acid_0002 | Acid_0414 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.874 |
Acid_0002 | tdk | Acid_0002 | Acid_3198 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase. | 0.461 |
Acid_0415 | dut | Acid_0415 | Acid_0414 | Alternative thymidylate synthase-like protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.671 |
Acid_1665 | Acid_0002 | Acid_1665 | Acid_0002 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.870 |
Acid_1665 | dut | Acid_1665 | Acid_0414 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.897 |
Acid_1665 | ndk | Acid_1665 | Acid_3376 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.919 |
Acid_1665 | tdk | Acid_1665 | Acid_3198 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase. | 0.495 |
Acid_1665 | tmk | Acid_1665 | Acid_4038 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate kinase / thymidylate synthase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.941 |
Acid_1665 | tmk-2 | Acid_1665 | Acid_7330 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.934 |
Acid_2351 | dut | Acid_2351 | Acid_0414 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.970 |
Acid_2599 | Acid_2632 | Acid_2599 | Acid_2632 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.905 |
Acid_2599 | dut | Acid_2599 | Acid_0414 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.941 |
Acid_2599 | tdk | Acid_2599 | Acid_3198 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase. | 0.936 |
Acid_2599 | tmk | Acid_2599 | Acid_4038 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | Thymidylate kinase / thymidylate synthase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.924 |
Acid_2599 | tmk-2 | Acid_2599 | Acid_7330 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.924 |
Acid_2632 | Acid_2599 | Acid_2632 | Acid_2599 | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: mag:amb2697 deoxycytidylate deaminase. | 0.905 |
Acid_2632 | dut | Acid_2632 | Acid_0414 | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Acid_2632 | tdk | Acid_2632 | Acid_3198 | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase. | 0.932 |
Acid_2632 | tmk | Acid_2632 | Acid_4038 | PFAM: metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase / thymidylate synthase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.911 |