STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Acid_0439KEGG: nha:Nham_3998 putative DNA topoisomerase I. (353 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.911
Acid_7732
DNA topoisomerase III; KEGG: cac:CAC3567 topoisomerase B; TIGRFAM: ATP-dependent DNA helicase, RecQ family; DNA topoisomerase III; PFAM: helicase domain protein; HRDC domain protein; TOPRIM domain protein; DEAD/DEAH box helicase domain protein; DNA topoisomerase, type IA, central domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein; DEAD-like helicases-like.
    
 
 0.910
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
    
 
 0.846
Acid_0740
ATP-dependent DNA helicase, RecQ family; KEGG: nfa:nfa2960 putative ATP-dependent DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like.
    
 
 0.808
Acid_0959
KEGG: aba:Acid345_3541 ATP-dependent DNA helicase, RecQ family; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like.
    
 
 0.808
Acid_2693
KEGG: bxe:Bxe_B1169 hypothetical protein.
 
    0.677
Acid_6821
PFAM: ATP dependent DNA ligase; KEGG: ret:RHE_PE00252 putative ATP-dependent DNA ligase protein.
 
 
 
 0.670
Acid_0438
PFAM: cyclic nucleotide-binding; ATP-binding region, ATPase domain protein domain protein; KEGG: gvi:gll1662 similar to two-component sensor histidine kinase.
     
 0.665
Acid_7844
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: pcu:pc1833 hypothetical protein.
 
 
 
 0.664
Acid_3033
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03959 hypothetical protein.
 
 
 
 0.657
Your Current Organism:
Solibacter usitatus
NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076
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