node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acid_2034 | Acid_6319 | Acid_2034 | Acid_6319 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.802 |
Acid_2034 | Acid_6320 | Acid_2034 | Acid_6320 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | PFAM: Heat shock protein 70; KEGG: tma:TM0373 dnaK protein. | 0.949 |
Acid_2034 | dnaK | Acid_2034 | Acid_7484 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
Acid_2034 | groL | Acid_2034 | Acid_6747 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.840 |
Acid_2034 | grpE | Acid_2034 | Acid_0733 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.847 |
Acid_2034 | hrcA | Acid_2034 | Acid_0732 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.800 |
Acid_2034 | rplP | Acid_2034 | Acid_5111 | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.681 |
Acid_6318 | Acid_6319 | Acid_6318 | Acid_6319 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.960 |
Acid_6318 | Acid_6320 | Acid_6318 | Acid_6320 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | PFAM: Heat shock protein 70; KEGG: tma:TM0373 dnaK protein. | 0.975 |
Acid_6318 | dnaK | Acid_6318 | Acid_7484 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.878 |
Acid_6318 | groL | Acid_6318 | Acid_6747 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.814 |
Acid_6318 | grpE | Acid_6318 | Acid_0733 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.802 |
Acid_6318 | hrcA | Acid_6318 | Acid_0732 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.800 |
Acid_6318 | rplP | Acid_6318 | Acid_5111 | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.681 |
Acid_6319 | Acid_2034 | Acid_6319 | Acid_2034 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: heat shock protein DnaJ domain protein; KEGG: mlo:mlr0945 probable heat shock protein. | 0.802 |
Acid_6319 | Acid_6318 | Acid_6319 | Acid_6318 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: heat shock protein DnaJ domain protein; KEGG: mma:MM1381 chaperone protein. | 0.960 |
Acid_6319 | Acid_6320 | Acid_6319 | Acid_6320 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: Heat shock protein 70; KEGG: tma:TM0373 dnaK protein. | 0.979 |
Acid_6319 | dnaJ | Acid_6319 | Acid_0734 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.802 |
Acid_6319 | dnaJ-2 | Acid_6319 | Acid_7483 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Chaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.802 |
Acid_6319 | dnaK | Acid_6319 | Acid_7484 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.915 |