STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
odhA2-oxoglutarate dehydrogenase complex E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (950 aa)    
Predicted Functional Partners:
GK1024
2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
GK1061
Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex).
 
 0.991
GK2379
Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase).
 
 0.991
GK2376
Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase).
 0.983
sucC
succinyl-CoA synthetase beta subunit (succinate-CoA ligase beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.982
GK2735
Isocitrate dehyrogenase.
   
 
 0.979
GK1060
Dihydrolipoamide acetyltransferase (E2 component of pyruvate dehydrogenase complex).
 0.978
GK0712
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase).
 0.975
GK3218
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase).
 0.967
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.962
Your Current Organism:
Geobacillus kaustophilus
NCBI taxonomy Id: 235909
Other names: G. kaustophilus HTA426, Geobacillus kaustophilus HTA426
Server load: low (34%) [HD]