node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK0717 | GK1775 | GK0717 | GK1775 | Hypothetical conserved protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.943 |
GK0717 | folD | GK0717 | GK2396 | Hypothetical conserved protein. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
GK0717 | gcvT | GK0717 | GK2425 | Hypothetical conserved protein. | Glycine cleavage system T protein, aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.962 |
GK0717 | glyA | GK0717 | GK3369 | Hypothetical conserved protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
GK0717 | thyA | GK0717 | GK1776 | Hypothetical conserved protein. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.947 |
GK1763 | GK2983 | GK1763 | GK2983 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Hypothetical conserved protein; Belongs to the 5'-nucleotidase family. | 0.916 |
GK1763 | comEB | GK1763 | GK2516 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Similar to N-terminal region of late competence protein (DNA binding and uptake) (comEB 189 aa) of Bacillus licheniformis. | 0.904 |
GK1763 | tdk | GK1763 | GK3380 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.921 |
GK1763 | thyA | GK1763 | GK1776 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
GK1763 | tmk | GK1763 | GK0024 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.913 |
GK1775 | GK0717 | GK1775 | GK0717 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical conserved protein. | 0.943 |
GK1775 | comEB | GK1775 | GK2516 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Similar to N-terminal region of late competence protein (DNA binding and uptake) (comEB 189 aa) of Bacillus licheniformis. | 0.403 |
GK1775 | gcvT | GK1775 | GK2425 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein, aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.922 |
GK1775 | glyA | GK1775 | GK3369 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
GK1775 | tdk | GK1775 | GK3380 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidine kinase. | 0.450 |
GK1775 | thyA | GK1775 | GK1776 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
GK2983 | GK1763 | GK2983 | GK1763 | Hypothetical conserved protein; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.916 |
GK2983 | comEB | GK2983 | GK2516 | Hypothetical conserved protein; Belongs to the 5'-nucleotidase family. | Similar to N-terminal region of late competence protein (DNA binding and uptake) (comEB 189 aa) of Bacillus licheniformis. | 0.904 |
GK2983 | tdk | GK2983 | GK3380 | Hypothetical conserved protein; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.903 |
GK2983 | thyA | GK2983 | GK1776 | Hypothetical conserved protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.911 |