STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIIABAnti-sigma F factor (serine kinase) (stage II sporulation protein AB); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)    
Predicted Functional Partners:
GK2310
Anti-sigma F factor antagonist (stage II sporulation protein AA); Belongs to the anti-sigma-factor antagonist family.
 
 
 0.998
sigF
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 
 0.996
spoIIGA
Protease (sporulation sigma-E factor processing peptidase); Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
  
  
 0.918
GK0367
Hypothetical conserved protein.
  
 
 0.865
GK2305
Stage V sporulation protein AC.
 
   
 0.862
GK2304
Stage V sporulation protein AD.
 
  
 0.855
sigG
DNA-directed RNA polymerase sporulation-specific sigma factor (sigma-G); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.852
GK2303
Sporulation protein.
 
     0.840
spoIVA
Stage IV sporulation protein A (spore cortex formation and coat assembly); ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
  
 0.826
spoIIR
Stage II sporulation protein R (pro-sigma-E processing factor).
  
   
 0.823
Your Current Organism:
Geobacillus kaustophilus
NCBI taxonomy Id: 235909
Other names: G. kaustophilus HTA426, Geobacillus kaustophilus HTA426
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