node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK1061 | GK1431 | GK1061 | GK1431 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Glutamate synthaselarge subunit. | 0.889 |
GK1061 | GK2379 | GK1061 | GK2379 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 0.910 |
GK1061 | gcvH | GK1061 | GK3004 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.977 |
GK1061 | gcvPA | GK1061 | GK2424 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.935 |
GK1061 | gcvPB | GK1061 | GK2423 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.938 |
GK1061 | gcvT | GK1061 | GK2425 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Glycine cleavage system T protein, aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |
GK1061 | glnA | GK1061 | GK1327 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Glutamine synthetase (glutamate-ammonia ligase). | 0.832 |
GK1061 | glyA | GK1061 | GK3369 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
GK1061 | purQ | GK1061 | GK0262 | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | Phosphoribosylformylglycinamidine (FGAM) synthasecomponent I (glutamine amidotransferase domain); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS int [...] | 0.808 |
GK1431 | GK1061 | GK1431 | GK1061 | Glutamate synthaselarge subunit. | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | 0.889 |
GK1431 | GK2379 | GK1431 | GK2379 | Glutamate synthaselarge subunit. | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 0.889 |
GK1431 | gcvH | GK1431 | GK3004 | Glutamate synthaselarge subunit. | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.887 |
GK1431 | gcvPA | GK1431 | GK2424 | Glutamate synthaselarge subunit. | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.891 |
GK1431 | gcvPB | GK1431 | GK2423 | Glutamate synthaselarge subunit. | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.898 |
GK1431 | gcvT | GK1431 | GK2425 | Glutamate synthaselarge subunit. | Glycine cleavage system T protein, aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.909 |
GK1431 | glnA | GK1431 | GK1327 | Glutamate synthaselarge subunit. | Glutamine synthetase (glutamate-ammonia ligase). | 0.983 |
GK1431 | glyA | GK1431 | GK3369 | Glutamate synthaselarge subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.488 |
GK1431 | purQ | GK1431 | GK0262 | Glutamate synthaselarge subunit. | Phosphoribosylformylglycinamidine (FGAM) synthasecomponent I (glutamine amidotransferase domain); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS int [...] | 0.902 |
GK2379 | GK1061 | GK2379 | GK1061 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Dihydrolipoamide dehydrogenase (E3 component of pyruvate complex). | 0.910 |
GK2379 | GK1431 | GK2379 | GK1431 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Glutamate synthaselarge subunit. | 0.889 |